This session from Sleep DownUnder 2025 brings together some of the leading evidence-based and intervention-based shift work research from Australian researchers. Each year, the sleep loss and body clock disruption caused by night work cost the economy $2–3 billion in lost productivity, impaired well-being, and poor health. Current regulations limit sequences of night shifts to a maximum of four in a row. However, recent research suggests this blanket limit may be a well-intentioned but ill-informed policy. As a result, we may be inadvertently increasing, rather than reducing, work-related fatigue.