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Obesity is a major risk factor for obstructive sleep apnea (OSA), contributing to airway obstruction, reduced lung function, and increased disease severity. This clinical session from Sleep DownUnder 2025 explores the complex relationship between obesity and OSA, highlighting the physiological mechanisms linking excess weight to sleep-disordered breathing. It also reviews the latest advances in weight management strategies, including lifestyle interventions, bariatric surgery, and pharmacological treatments such as GLP-1 receptor agonists.